It was obvious-to me at any rate-that the answer was to why an enzyme is able to speed up a chemical reaction by as much as 10 million times. It had to do this by lowering the energy of activation-the energy of forming the activated complex. It could do this by forming strong bonds with the activated complex, but only weak bonds with the reactants or products.
Linus PaulingMen will gather knowledge no matter what the consequences. Science will go on whether we are pessimistic or optimistic, as I am. More interesting discoveries than we can imagine will be made, and I am awaiting them, full of curiosity and enthusiasm.
Linus PaulingAn amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations.
Linus PaulingDoes the commandment 'Thou Shalt Not Kill' mean nothing to us? Are we to interpret it as meaning 'Thou shalt not kill except on the grand scale,' or 'Thou shalt not kill except when the national leaders say to do so'?
Linus PaulingIt was obvious-to me at any rate-that the answer was to why an enzyme is able to speed up a chemical reaction by as much as 10 million times. It had to do this by lowering the energy of activation-the energy of forming the activated complex. It could do this by forming strong bonds with the activated complex, but only weak bonds with the reactants or products.
Linus Pauling