Consider the clinicaltrials by which drugs are tested in human subjects.5 Before a new drug can enter the market, its manufacturer must sponsor clinicaltrials to show the Food and Drug Administration that the drug is safe and effective, usually as compared with a placebo or dummy pill. The results of all the trials (there may be many) are submitted to the FDA, and if one or two trials are positiveโthat is, they show effectiveness without serious riskโthe drug is usually approved, even if all the other trials are negative.
Marcia AngellPharmaceutical companies have too much influence over the education of physicians in this country. They have too much control over the evaluation of their own products, and that's a conflict of interest. I think the industry needs to be regulated, but I've never suggested taking it out of the market altogether.
Marcia AngellWhy should anyone - the state, the medical profession, or anyone else - presume to tell someone else how much suffering they must endure as their life is ending?
Marcia AngellDrug companies say they need to charge ever-higher prices to cover their research costs, but they spend far less on research and development than they do on marketing and administration, and afterwards they actually keep more in profits.
Marcia Angell