So much for endings. Beginnings are always more fun. True connoisseurs, however, are known to favor the stretch in between, since it's the hardest to do anything with. That's about all that can be said for plots, which anyway are just one thing after another, a what and a what and a what.

When we cracked the genetic DNA code, opened the big Pandora's box, and it really did become possible to produce chimeras, my ears shot up. Having been brought up among the biologists and having followed various debates about ways to improve the human template and other debates about the true nature of our nature, I began seriously to wonder: What if? We hold in our hands a tool that is more powerful - for good or ill - than any we have wielded before.

In the First World War, people would be receiving letters from loved ones who had been dead for weeks, and they would not know until that black-bordered telegram arrived. I remember, of course, when it was letters only, or the telephone, and you did not make expensive long-distance calls unless it was, "Come home to the funeral," or the like.

But maybe, underneath, she loves him too much. Maybe it's her excessive love that pushes him away.

Truly amazing, what people can get used to, as long as there are a few compensations.

Every ending is arbitrary, because the end is where you write The end. A period, a dot of punctuation, a point of stasis. A pinprick in the paper: you could put your eye to it and see through, to the other side, to the beginning of something else. Or, as Tony says to her students, Time is not a solid, like wood, but a fluid, like water or the wind. It doesn't come neatly cut into even-sized length, into decades and centuries. Nevertheless, for our purposes we have to pretend it does. The end of any history is a lie in which we all agree to conspire.

I'll make you mine, lovers said in old books. They never said, I'll make you me.