A man that is ashamed of passions that are natural and reasonable is generally proud of those that are shameful and silly.

One can never outlive one's vanity.

[On her political writings:] It is, I confess, very possible that these my Labours may only be destined to line Trunks, or preserve roast Meat from too fierce a Fire; yet in that Shape I shall be useful to my Country.

My dear Smollett ... disgraces his talent by writing those stupid romances called history.

I am patriot enough to take pains to bring this usefull invention into fashion in England, and I should not fail to write to some of our Doctors very particularly about it, if I knew anyone of 'em that I thought had Virtue enough to destroy such a considerable branch of Revenue for the good of Mankind, but that Distemper is too beneficial to them not to expose to all their Resentment the hardy wight that should undertake to put an end to it.

It's in no way my interest (according to the common acceptance of that word) to convince the world of their errors; that is, I shall get nothing from it but the private satisfaction of having done good to mankind, and I know nobody that reckons that satisfaction any part of their interest.

Begin nothing without considering what the end may be.