The experience of climbing Kilimanjaro affected me so powerfully that, for a long time afterward, if I caught myself saying, "I'm not a person who likes to do that activity, eat that food, listen to that music," I would automatically go out and do what I imagined I didn't like. Generally I found I was wrong about myself - I liked what I thought I wouldn't like. And even if I didn't like the particular experience, I learned I liked having new experiences.

And that's how things are. A day is like a whole life. You start out doing one thing, but end up doing something else, plan to run an errand, but never get there. . . . And at the end of your life, your whole existence has the same haphazard quality, too. Your whole life has the same shape as a single day.

That's human nature. Nobody does anything until it's too late.

This novel is fiction, except for the parts that aren't.

She had been living like a hermit herself, in a cramped, seedy apartment in Somerville, spending long hours in the lab. All-nighters had become a regular thing. She didn't have any close friends, didn't go out on dates, didn't even go to the movies by herself. She had sacrificed a normal life in order to get a PhD, and become a scientist.

In science, the old men are usually wrong. But in politics, the old men are wise, counsel caution, and in the end are often right.

Conventional wisdom is invariably out of date. Because in the time it has taken to become conventional - to become what everyone believes - the world has moved on. Conventional wisdom is a remnant of the past.