Life is good, and there's no reason to think it won't be--right up until the moment when everything explodes into a fireball of tiny, unrecognizable fragments, or it all goes skidding sideways, through the guardrail, over the embankment, and down the mountain. This will happen (and probably more than once).

I think there's a God and I know it's not me. I don't have a set of tenets, but I live an ethical life.

So what I say about Tracy is this: Tracy's big challenge is not having a Parkinson's patient for a husband. It's having me for a husband. I happen to be a Parkinson's patient.

Humility is always a good thing. It's always a good thing to be humbled by circumstances so you can then come from a sincere place to try to deal with them.

People want leadership, Mr. President, and in the absence of genuine leadership, they'll listen to anyone who steps up to the microphone. They want leadership. They're so thirsty for it they'll crawl through the desert toward a mirage, and when they discover there's no water, they'll drink the sand.

Our challenges don’t define us, our actions do.

I mean, I enjoy my work as an actor. But to make a difference in people's lives through advocacy and through supporting research - that's the kind of privilege that few people will get, and it's certainly bigger than being on TV every Thursday for half an hour.