[Constant curiousity leads to happiness:] I wake up curious every day and every day I'm surprised by something. And if I can just recognize that surprise every day and say, 'Oh, that's a new thing, that's a new gift that I got today that I didn't even know about yesterday,' it keeps me going. It keeps me more than going. It keeps me enthusiastic and grateful!

Lance Armstrong showed up, and I started talking to him; I saw all these people with cancer who followed him to Paris for the Tour de France, and I saw the difference he was making in their lives. That put it together for me...having it be not so much about me, but [my being] a vehicle for it.

People want leadership, Mr. President, and in the absence of genuine leadership, they'll listen to anyone who steps up to the microphone. They want leadership. They're so thirsty for it they'll crawl through the desert toward a mirage, and when they discover there's no water, they'll drink the sand.

If you were to rush into this room right now and announce that you had struck a deal - with God, Allah, Buddha, Christ, Krishna, Bill Gates, whomever - in which the ten years since my diagnosis could be magically taken away, traded in for ten more years as the person I was before - I would, without a moment's hesitation, tell you to take a hike.

I remember my son wanted to go to bed with his cowboy boots on, and we had this fight for like an hour. Then I realized that the only good reason I had for him not to do it is because I didn't want him to. There was really no other reason. And finally I said, "OK, fine." It was a great victory for me, because I realized it doesn't really matter.

There's always failure. And there's always disappointment. And there's always loss. But the secret is learning from the loss, and realizing that none of those holes are vacuums.

Medical science has proven time and again that when the resources are provided, great progress in the treatment, cure, and prevention of disease can occur.