When you're doing lots and lots of episodes and you're playing the same character, it's great because you really get to know the character and it becomes a really fast style and you find subtleties in it.

I actually think that the most efficacious way of making a difference is to lead by example, and doing random acts of kindness is setting a very good example of how to behave in the world.

If God is watching your every move, you should probably straighten up your act a little bit.

When the Haiti earthquake happened, I registered with UNICEF to set up an account, and posted to Twitter for people to donate to it. In a matter of a couple of hours, $30,000 had been donated. That, to me, was eye-opening.

I think participating in "Gishwhes" is a crash course in facing our fears: people go to crowded shopping malls wearing scuba gear, order from a fast food restaurant in Shakespearean verse or jump out of airplanes among many other tasks.

I had a moment when I first got on Supernatural when I was like, omg, people are paying attention to me and I have fans, maybe I should cultivate an image and like try to seem really cool. I had this sort of moment of being commercially self conscious, and it took me maybe a month to realize, no, this is just not fucking who I am... Here's a picture of me in drag, fuck it - which is, by the way, so much more liberating and relaxing... There's not a more surefire way to give a stifled boring empty vapid meaningless piece of interview. Everything that comes out of your mouth sucks if you're trying to say the right thing...

Perhaps I shifted from "me" to "we" when I realized that "I" could get a lot more done with "us."