Sometimes they come to you and it's a small role, so it's about the experience and the journey and mixing with people you know you will learn from. Or sometimes it's a scene in a movie that you think, 'I just have to play this person.'

I got knockback after knockback at auditions. Just before ‘Mulholland Dr.’ my agent told me I was so intense I was freaking people out. She told me I was a brilliant actor but the feedback was that I made people feel uncomfortable because I was so nervous and intense. I just sat there and blubbed. My mum was staying in LA at the time and I went to her and said: ‘I just can’t do this. I’m not cut out for it.’ She just said: ‘Don’t believe a word people say about you. Forget them.’

There's a set of rules out there somewhere that says it all ends by 40. I hope to be able to defy that because I truly love my work.

We're so afraid of death in our culture, but I think if we understand it better, then we'll appreciate the life we have more.

If we could just trust the moment that we're in and live it in the way that you best can embrace it, it would be much better for all of us.

Never say never - and I certainly don't judge anyone who does it. But most of the characters I play are going through some kind of emotional turmoil, so my job requires me to have expression. If my face was froze, what right do I have to play that part? All the women who haven't done anything to their faces are still able to play great roles. And some of the ones who have done something have messed it up - they look freakish. Anyway, for me it's about playing women with rich lives - and the longer the life, the deeper the wrinkles.

It's always nerve-racking to take off your clothes on film. But doing it with a woman felt safer than with a man. You know you can say, 'Don't grab me there: That's where my cellulite is'!