The secret to comedy is not playing the comedy, but actually playing the situation, playing the drama of it.

I love when a TV show, or entertainment in general, makes me feel something; be it positive, be it negative, be it happiness, be it awkward, uncomfortable if it can make me feel, it's done it's job.

No one wants to see a person on TV who's super-ultra-cool. That's Superman, that's a thing of the past. Heroes are now flawed, and have terrible tempers, you know? They're real people.

I would cancel dialysis to be in the [hopefully upcoming Firefly] movie.

I told myself a while back, 'Love what you do, but don't fall in love with what you do.' That way you won't be brokenhearted if ever it gets canceled five episodes in - which has happened to me.

I don't spend a lot of time online. My mother's really good at picking out if she sees a really great review, and she'll forward it to me. She's like my little Internet filter. It's always nice to see something going up; if I want to find something on Nathan Fillion, I do know where to look, but I've got a nice little delivery system in my mom.

When I watch TV I can tell when someone is punching the joke and telling me when to laugh (I’ll decide when to laugh, thank you very much).