We know there are certain types of viruses that are nasty - influenza, for instance, is an area that is not a blindside. But a lot of viruses have come out of nowhere, like H.I.V., or to a certain extent SARS. Because we know we have the potential to be blindsided, we really have to investigate the unknowns.

I work to create systems that can accurately detect pandemics early, determine their likely importance, and, with any luck, crush those that have the potential to devastate us.

About 20 percent of the genetic information in your nose doesn't match anything that we've ever seen before.

We may have charted all the continents on the planet, and we may have discovered all the mammals, but that doesn't mean that there's nothing left to explore on Earth.

Don't assume that what we currently think is out there is the full story. Go after the dark matter, in whatever field you choose to explore.

If you find diseases before they've really emerged, you can control them early on, before you get a major epidemic.

The world can now maintain an acute infection in a way that is unprecedented in the history of life on our planet.