The human brain works as a binary computer and can only analyze the exact information-based zeros and ones (or black and white). Our heart is more like a chemical computer that uses fuzzy logic to analyze information that can't be easily defined in zeros and ones.

Successful entrepreneurs find the balance between listening to their inner voice and staying persistent in driving for success - because sometimes success is waiting right across from the transitional bump that's disguised as failure.

I believe that entrepreneurs play an unmatched role and the accelerating pace of innovation is transforming the face of global challenges. You must think about the solution differently when you're trying to impact 1 billion people rather than affecting 1 million people.

The U.S. has spent billions of dollars on educating and supporting teachers or developing curricula but no resources are applied to 'improving the brain' that a student brings to the classroom.

Athletes at all ages are bigger and stronger than ever before. And they are being encouraged - sometimes even incentivized, as we recently learned was the case on at least one National Football League team - to play to injure.

Philanthropy is not about giving money but about solving problems. While well-meaning, the idea of writing a check and calling it 'philanthropy' is extremely short-sighted and, unfortunately, extremely pervasive.

I started off with a company, InfoSpace, with my own funding. The company was listed among the most successful companies and I went on to start Intelius and Moon Express. Now, I focus my time on using the skills of an entrepreneur to solve many of the grand challenges facing us in the areas of education, healthcare, clean water and energy.