I grew up poor in India, and there were days when we struggled to find food and other basic necessities. Our mother worked odds and ends jobs to keep the family together and educate us.

I believe our legacy will be defined by the accomplishments and fearless nature by which our daughters and sons take on the global challenges we face. I also wonder if perhaps the most lasting expression of one's humility lies in our ability to foster and mentor our children.

My parents didn't believe in luck. They believed in hard work and in preparing me to take advantage of opportunity. Like many parents, they taught me to be generous but never to depend on the generosity of others.

Stay focused on the mission.

The U.S. has spent billions of dollars on educating and supporting teachers or developing curricula but no resources are applied to 'improving the brain' that a student brings to the classroom.

I believe that entrepreneurs play an unmatched role and the accelerating pace of innovation is transforming the face of global challenges. You must think about the solution differently when you're trying to impact 1 billion people rather than affecting 1 million people.

There are as many ways to help another human being as there are people in need of help. For some, the urgent need is as basic as food and water. For others, it is an opportunity to develop a talent, realize an idea, and reach one's full potential.