Trust your gut instinct over spreadsheets. There are too many variables in the real world that you simply can't put into a spreadsheet. Spreadsheets spit out results from your inexact assumptions and give you a false sense of security. In most cases, your heart and gut are still your best guide.

How important is failure - yes, failure - to the health of a thriving, innovative business? So important that Ratan Tata, chairman of India's largest corporation, gives an annual award to the employee who comes up with the best idea that failed.

I believe we need a more opportunistic and democratic approach to lunar exploration, now that we're shifting from U.S. government-sponsored space exploration to private expeditions.

I believe that entrepreneurs play an unmatched role and the accelerating pace of innovation is transforming the face of global challenges. You must think about the solution differently when you're trying to impact 1 billion people rather than affecting 1 million people.

There are as many ways to help another human being as there are people in need of help. For some, the urgent need is as basic as food and water. For others, it is an opportunity to develop a talent, realize an idea, and reach one's full potential.

Success is not about how much money we have in the bank, but it's about how many peoples' lives we have impacted through it. Success is experienced when we do things which are never done before.

Humans have always used our intelligence and creativity to improve our existence. After all, we invented the wheel, discovered how to make fire, invented the printing press and found a vaccine for polio.