In science, if you don't do it, somebody else will. Whereas in art, if Beethoven didn't compose the 'Ninth Symphony,' no one else before or after is going to compose the 'Ninth Symphony' that he composed; no one else is going to paint 'Starry Night' by van Gogh.

... informed ignorance provides the natural state of mind for research scientists at the ever-shifting frontiers of knowledge. People who believe themselves ignorant of nothing have neither looked for, nor stumbled upon, the boundary between what is known and unknown in the cosmos.

I'm optimistic. I see no longer people accepting fuzzy thinking in the world. The change is not that people aren't still saying under-informed things. The change is that if you're in power and you say something under-informed, there are people out there with a voice who will take you to task for having done so

Don't know if it's good or bad that a Google search on “Big Bang Theory” lists the sitcom before the origin of the Universe

I want to create the airplane that flies in the rarified atmosphere of Mars. This is what galvanizes a generation to want to become scientists and engineers in the first place, not we need a scientist to develop a plane that's 20 percent more fuel-efficient than the one your parents flew.

Wanting to do one thing can require that you take on other interests.

When NASA dreams big America dreams big. People...kids say, 'I want to do that when I grow up'. Because you want to do what's visible to you.