If I had cast someone else who didn't have that kind of timing, it would have been leaden and one note. But Ann [Morgan Guilbert] made her really human and really funny without being caricatured or over the top. She feels like a real person.

My idea of no makeup on actors is really no makeup. I mean, they can be wearing makeup. I don't care what they're wearing as long as it looks like they're not wearing makeup. But an actress will suddenly appear with some lipstick on. And that's makeup. Keener's character wears makeup. Her character would wear makeup. I try to stay true to whoever that person is. I hate that kind of thing where you're waking up in the morning with makeup on in a movie. I just think it pulls you out of the movie.

The pieces of "Please Give" just did fit together. I'm very comfortable with the ensemble. I thought this was just going to be a movie about this girl who gives mammograms. She's the lead. And then before I know it, she's got a sister, neighbors, and sometimes parents and friends and then it's an ensemble. And that's what I'm comfortable with, I guess.

I have a boundary problem... I need to know when to give and when to back up. I'll help someone across the street and then into their homes and they'll start telling me all their problems... and it turns out they're insane and want to kill me. I've got to know when to stop!

I always had good friends, but I did not feel like a cool girl, ever.

What are we taking from people and what do we give is a life-long struggle, I think, for most of us. Who are we? Do we like who we are? Do we know who we are? Do we care? Does anyone care? That's such a big topic. I could tackle that in many movies. So could other people.

If I had cast someone else who didn't have that kind of timing, it would have been leaden and one note. But Ann [Morgan Guilbert] made her really human and really funny without being caricatured or over the top. She feels like a real person.