Fame is fleeting. Sometimes people like you, sometimes they don’t. Not all people are going to like you.

Oh, she's my bodyguard. I mean, I'm a married man, and the last thing you need in that situation is to be considered a sexy individual. But I try to never let this whole McDreamy thing really influence us. I'm trying to just have a calm family life, to make my marriage work. It's not as if when my wife asks me to take out the trash, I say, 'Um, honey, don't you realize that I'm too sexy for that'? Well, actually, I do, but she gives me crap for it.

I love having a big family. I think it's easier, oddly, in some ways, having three children as opposed to one.

And, sure, if you have a political point of view, you have every right to share it. But you have to be careful not to get too self-important. You have to find the balance between being entertaining and being preachy.

Now I'm just known as McDreamy, I've lost all identity as Patrick Dempsey, I'm now McDreamy.

Sometimes in television, if there are storylines that are oft-told, people can be hypercritical of them.

Housekeeping is incredibly difficult with three kids. I'm trying to be more relaxed. You'll go insane if you try to have a picture-book house