For the most part, the best opportunities now lie where your competitors have yet to establish themselves, not where they're already entrenched. Microsoft is struggling to adapt to that new reality.

As a species, we've always been discoverers and adventurers, and space and the deep ocean are some of the last frontiers.

In a company where tech decisions were still ultracentralized, the repercussions of a distracted CEO had to be damaging.

Sometimes it's very difficult to find fresh fruit on the road.

That would be such a life-changing thing, for us all to know that there are other beings out there who we could potentially communicate with, or maybe we are listening to a signal that they transmitted hundreds of millennia ago.

I was in a town of about 10,000 people, and a shipping container with a rusty microscope was their medical clinic.

The only regrets I have are rather prosaic - like I wish I went for a swim in the Pacific.