Wheeler hopes that we can discover, within the context of physics, a principle that will enable the universe to come into existence "of its own accord." In his search for such a theory, he remarks: "No guiding principle would seem more powerful than the requirement that it should provide the universe with a way to come into being." Wheeler likened this 'self-causing' universe to a self-excited circuit in electronics.

The way life manages information involves a logical structure that differs fundamentally from mere complex chemistry. Therefore chemistry alone will not explain life's origin, any more than a study of silicon, copper and plastic will explain how a computer can execute a program.

Many investigators feel uneasy stating in public that the origin of life is a mystery, even though behind closed doors they admit they are baffled.

The temptation to believe that the Universe is the product of some sort of design, a manifestation of subtle aesthetic and mathematical judgment, is overwhelming. The belief that there is "something behind it all" is one that I personally share with, I suspect, a majority of physicists.

Perhaps the best motivation for going to Mars is political. It is obvious that no single nation currently has either the will or the resources to do it alone, but a consortium of nations and space agencies could achieve it within 20 years.

Through my scientific work I have come to believe more and more strongly that the physical universe is put together with an ingenuity so astonishing that I cannot accept it as a brute fact....I cannot believe that our existence in this universe is a mere quirk of fate, an accident of history, an incidental blip in the great cosmic drama.

The development of artificial intelligence may well imply that man will relinquish his intellectual supremacy in favor of thinking machines. With oceans of time available for future innovation, there seems to be no reason why machines cannot achieve and surpass anything of which the human brain is capable.