It can be easy and comfortable on the set and you don't go anywhere, or it can be a stress machine and all of a sudden it's a hit.

I think if I learned anything in graduate school, it was to not drool around other actors who would normally make you drool.

Bradley Cooper was an asshole, but he was - like Sidney Lumet, like George Clooney - the nicest guy in the world. I sound like the biggest ass-kisser ever. But I'm telling the truth, I swear to God!

I've never done real sci-fi. I've never played an alien. I've never played some sort of superhero. Which I'd love to do!

If you do an episode about something like transverse myelitis, it's a real disease that's out there, there are a lot of people that have it, and it's hard to get funding for them because people don't know about it. There are actually a lot of doctors that don't know about it. But if you do an episode of House, all of a sudden 15 million people are hearing the words, and it's an opportunity.

Every actor wants to do more, because you always think you can improve it.

We walked out of this library building downtown, just on our way to lunch, and I was walking a few steps behind Travolta, and when he opened the door, it was as if Jesus had just walked out into the commons.