Look at Mann's reading habits, his explicit comments on Nietzsche, and his copy of Birth of Tragedy, and it starts to seem doubtful that this work of Nietzsche's played much role in the gestation of the novella.

A different vision of ethics is that of a collection of resources people can use to act better. The resources might be firm rules that could always be relied on. Or they might be ideals that could often be followed without thinking but that sometimes conflicted with one another.

Schopenhauer's thought that Will is insatiable, that once satisfied in one form it must be expressed in new desires, is inherited both by Mann and by Aschenbach (it's in Mahler, as well). So life is inevitably incomplete.

I argue against literal interpretation of religious doctrines. Religions make progress when they emancipate themselves from literalism, and take their doctrinal statements to be metaphors or allegories.

The amalgam of psychological attitudes we form is the synthetic complex. It may fall apart quite quickly as further reflection or further experience bears on it, and we may revert to our former judgments, feelings and tendencies.

Mann was conscious of adopting different perspectives in different parts of the novella, but my guess is that there are plenty of passages in which the resonance of the words he chose struck him as exactly right (even though he didn't probe to discover exactly what tone or narrative device gave them that effect).

If there are to be appropriate judgments about what questions are significant, you need both the informed views of scientists who know what has been achieved and what future developments are promising and the reflective judgments of representatives of different groups who can identify what kinds of information are most urgently needed.