I had parents who believed I could do anything - and I know how that made me feel. I think both my parents, having careers in the medical profession, feel they are helping people on a daily basis, and that was inculcated in me as a value. I had to struggle with giving up the idea of becoming a doctor myself.

Men rise through the ranks because of potential, but women have to prove themselves - while trying to have children and having no family leave.

I was talking to my friend who's a psychologist, who says a woman's frontal cortex isn't fully developed till 25 and a man's till 28. I was almost 34 when we met; he was 39. So I wouldn't say either of us has wildly changed; I just love him more and more.

Art is art. Television has elevated itself, in certain ways, but it's always pushed people's consciousness.

We’re more than just our dresses.

I always let my husband read the script so he knows what's about to happen to his wife. When I played Cheryl Strayed in Wild, I'd get really mad about certain things, I'd say really profound things, and I'd curse out of nowhere. He'd say, "Are you you, or are you Cheryl?"

When people get in your face and say, 'This will pass,' you think, Are they crazy? I'm never gonna feel any better than I feel right this minute and nothing's ever gonna make sense again... You see a lot of people play this blame game. Blame, blame, blame. You know? And it's a really easy thing to do, and I'm certainly guilty of it. [You have to] look at yourself and go, 'What part of this do I need to own? Which part of this is my responsibility?' And that's the painful work that you have to go through to hopefully get some real life knowledge out of it.