I am thinking, therefore I exist. (...) I was a substance whose whole essence or nature is solely to think, and which does not require any place, or depend on any material thing, in order to exist. Accordingly this 'I' - that is, the soul by which I am what I am - is entirely distinct from the body, and indeed is easier to know than the body, and would not fail to be whatever it is, even if the body did not exist.
Rene DescartesThere is a little gland in the brain in which the soul exercises its functions in a more particular way than in the other parts.
Rene Descartes