Pathological states are the consequence of several determinate factors acting simultaneously...The manifestations of any given agent differ profoundly from one person to another. ...Each noxious agent can express itself by a great variety of different pathological states. ...Different agents can elicit similar reactions. ...The total environment and the (interior medium) constitute a multifactorial system.

It is possible to analyze the biological and social influences that make each human being unique, unprecedented, and unrepeatable, but this analysis does not explain how and why each feels different from all other human beings.

But too often the goal of the planners is a universal gray state of health corresponding to absence of disease rather than to a positive attribute conducive to joyful and creative living. This kind of health will not rule out and may even generate another form of ill, the boredom which is the penalty of a formula of life where nothing is left unforeseen.

The very process of living is a continual interplay between the individual and his environment, often taking the form of a struggle resulting in injury or disease.

With reference to life there is not one nature; there are only associations of states and circumstances, varying from place to place and from time to time.

In man, at least, satisfaction is commonly followed by boredom.

Man could escape danger only by renouncing adventure, by abandoning that which has given to the human condition its unique character and genius among the rest of living things.