The principle of science, the definition, almost, is the following: The test of all knowledge is experiment. Experiment is the sole judge of scientific "truth." But what is the source of knowledge? Where do the laws that are to be tested come from? Experiment, itself, helps to produce these laws, in the sense that it gives us hints. But also needed is imagination to create from these hints the great generalizations--to guess at the wonderful, simple, but very strange patterns beneath them all, and then to experiment to check again whether we have made the right guess.

To do any important work in physics a very good mathematical ability and aptitude are required. Some work in applications can be done without this, but it will not be very inspired. If you must satisfy your "personal curiosity concerning the mysteries of nature" what will happen if these mysteries turn out to be laws expressed in mathematical terms (as they do turn out to be)? You cannot understand the physical world in any deep or satisfying way without using mathematical reasoning with facility.

It is in the admission of ignorance and the admission of uncertainty that there is a hope for the continuous motion of human beings in some direction that doesn't get confined, permanently blocked, as it has so many times before in various periods in the history of man.

It doesn't matter how beautiful your theory is, it doesn't matter how smart you are. If it doesn't agree with experiment, it's wrong.

The thing that doesn't fit is the thing that is most interesting.

Philosophy of science is about as useful to scientists as ornithology is to birds.

An ordinary fool isn't a faker; an honest fool is all right. But a dishonest fool is terrible!