First you guess. Don't laugh, this is the most important step. Then you compute the consequences. Compare the consequences to experience. If it disagrees with experience, the guess is wrong. In that simple statement is the key to science. It doesn't matter how beautiful your guess is or how smart you are or what your name is. If it disagrees with experience, it's wrong. That's all there is to it.

From a long view of the history of mankind the most significant event of the nineteenth century will be judged as Maxwell's discovery of the laws of electrodynamics.

Fall in love with some activity, and do it! Nobody ever figures out what life is all about, and it doesn't matter.

No government has the right to decide on the truth of scientific principles, nor to prescribe in any way the character of the questions investigated. Neither may a government determine the aesthetic value of artistic creations, nor limit the forms of literacy or artistic expression. Nor should it pronounce on the validity of economic, historic, religious, or philosophical doctrines. Instead it has a duty to its citizens to maintain the freedom, to let those citizens contribute to the further adventure and the development of the human race.

Nature...cannot be fooled!

Experiment is the sole judge of the validity of any idea.

When things are going well, something will go wrong. / When things just can't get any worse, they will. / Anytime things appear to be going better, you have overlooked something.