First you guess. Don't laugh, this is the most important step. Then you compute the consequences. Compare the consequences to experience. If it disagrees with experience, the guess is wrong. In that simple statement is the key to science. It doesn't matter how beautiful your guess is or how smart you are or what your name is. If it disagrees with experience, it's wrong. That's all there is to it.

For far more marvelous is the truth than any artists of the past imagined it. Why do the poets of the present not speak of it? What men are poets who can speak of Jupiter if he were a man, but if he is an immense spinning sphere of methane and ammonia must be silent?

You have no responsibility to live up to what other people think you ought to accomplish. I have no responsibility to be like they expect me to be. It's their mistake, not my failing.

The world is a dynamic mess of jiggling things

... it is impossible to explain honestly the beauties of the laws of nature in a way that people can feel, without their having some deep understanding of mathematics. I am sorry, but this seems to be the case.

Philosophy of science is about as useful to scientists as ornithology is to birds.

So this piece of dirt waits four and a half billion years and evolves and changes, and now a strange creature stands here with instruments and talks to the strange creatures in the audience. What a wonderful world!