There are thousands of years in the past, and there is an unknown amount of time in the future. There are all kinds of opportunities, and there are all kinds of dangers.

Today's brains are yesterday's mashed potatoes.

First you guess. Don't laugh, this is the most important step. Then you compute the consequences. Compare the consequences to experience. If it disagrees with experience, the guess is wrong. In that simple statement is the key to science. It doesn't matter how beautiful your guess is or how smart you are or what your name is. If it disagrees with experience, it's wrong. That's all there is to it.

If you have any talent, or any occupation that delights you, do it, and do it to the hilt. Don't ask why, or what difficulties you may get into.

The problem of creating something new, but which is consistent with everything which has been seen before, is one of extreme difficulty.

The idea is to try to give all the information to help others to judge the value of your contribution; not just the information that leads to judgment in one particular direction or another.

Science is uncertain.