Ignorance is the Mother of Devotion.

We want to be known for having original ideas, inspired hunches, and gut feelings that make a difference. Indeed, a "well-honed sixth sense"' is considered a measure of the good clinician. But being a good doctor also requires sticking with the best medical evidence, even if it contradicts your personal experience. We need to distinguish between gut feeling and testable knowledge, between hunches and empirically tested evidence.

Ignorance is the Mother of Devotion.

Good science requires distinguishing between "felt knowledge" and knowledge arising out of testable observations. "I am sure" is a mental sensation, not a testable conclusion. Put hunches, gut feelings, and intuitions into the suggestion box. Let empiric methods shake out the good from bad suggestions.

Properly conducted scientific studies . . . give us a pretty good idea of when something is likely to be correct. To me, pretty good is a linguistic statistic that falls somewhere in between more likely than not and beyond a reasonable doubt, et avoides the pitfalls arising from the belief in complete objectivity.

Out of too much learning become mad.

Certainty and similar states of ‘knowing what we know’ arise out of involuntary brain mechanisms that, like love or anger, function independently of reason.