One was never married, and that's his hell; another is, and that's his plague.

Properly conducted scientific studies . . . give us a pretty good idea of when something is likely to be correct. To me, pretty good is a linguistic statistic that falls somewhere in between more likely than not and beyond a reasonable doubt, et avoides the pitfalls arising from the belief in complete objectivity.

Every schoolboy hath that famous testament of Grunnius Corocotta Porcellus at his fingers end.

Certainty and similar states of ‘knowing what we know’ arise out of involuntary brain mechanisms that, like love or anger, function independently of reason.

Tobacco, divine, rare, superexcellent tobacco, which goes far beyond all the panaceas, potable gold, and philosophers stones, a sovereign remedy to all diseases but as it is commonly abused by most men, which take it as tinkers do ale, 'Tis a plague, a mischief, a violent purger of goods, lands, health; hellish, devilish and damned tobacco, the ruin and overthrow of body and soul.

Certainty is not biologically possible. We must learn (and teach our children) to tolerate the unpleasantness of uncertainty. Science has given us the language and tools of probabilities. We have methods for analyzing and ranking opinion according to their likelihood of correctness. That is enough.

Our mental limitations prevent us from accepting our mental limitations.