Tobacco, divine, rare, superexcellent tobacco, which goes far beyond all the panaceas, potable gold, and philosophers stones, a sovereign remedy to all diseases but as it is commonly abused by most men, which take it as tinkers do ale, 'Tis a plague, a mischief, a violent purger of goods, lands, health; hellish, devilish and damned tobacco, the ruin and overthrow of body and soul.

Our mental limitations prevent us from accepting our mental limitations.

It is most true, stylus virum arguit, - our style betrays us.

Good science is more than the mechanics of research and experimentation. Good science requires that scientists look inward-to contemplate the origin of their thoughts. The failures of science do not begin with flawed evidence or fumbled statistics; they begin with personal self-deception and an unjustified sense of knowing.

Certainty is not biologically possible. We must learn (and teach our children) to tolerate the unpleasantness of uncertainty. Science has given us the language and tools of probabilities. We have methods for analyzing and ranking opinion according to their likelihood of correctness. That is enough.

We want to be known for having original ideas, inspired hunches, and gut feelings that make a difference. Indeed, a "well-honed sixth sense"' is considered a measure of the good clinician. But being a good doctor also requires sticking with the best medical evidence, even if it contradicts your personal experience. We need to distinguish between gut feeling and testable knowledge, between hunches and empirically tested evidence.

Out of too much learning become mad.