If I had to define a major depression in a single sentence, I would describe it as a "genetic/neurochemical disorder requiring a strong environmental trigger whose characteristic manifestation is an inability to appreciate sunsets.
Robert M. SapolskySome Poor grad student pressing on the flanks of a hamster and out comes a doctorate on the other side
Robert M. SapolskyBrains distinguish between an Us and a Them in a fraction of a second. Subliminal processing of a Them activates the amygdala and insular cortex, brain regions that are all about fear, anxiety, aggression, and disgust.
Robert M. SapolskyFossey, Fossey, you cranky difficult strong-arming self-destructive misanthrope, mediocre scientist, deceiver of earnest college students, probable cause of more deaths of the gorillas than if you had never set foot in Rwanda, Fossey, you pain-in-the-ass saint, I do not believe in prayers or souls, but I will pray for your soul, I will remember you for all of my days, in gratitude for that moment by the graves when all I felt was the pure, cleansing sadness of returning home and finding nothing but ghosts.
Robert M. Sapolsky