Abstinence is as easy to me as temperance would be difficult.

To write is, indeed, no unpleasing employment, when one sentiment readily produces another, and both ideas and expressions present themselves at the first summons; but such happiness, the greatest genius does not always obtain; and common writers know it only to such a degree, as to credit its possibility. Composition is, for the most part, an effort of slow diligence and steady perseverance, to which the mind is dragged by necessity or resolution, and from which the attention is every moment starting to more delightful amusements.

Invention is almost the only literary labour which blindness cannot obstruct.

It is incident to physicians, I am afraid, beyond all other men, to mistake subsequence for consequence.

I will venture to say there is more learning and science within the circumference of ten miles from where we now sit [in London], than in all the rest of the kingdom.

Where no man thinks himself under any obligation to submit to another, and, instead of co-operating in one great scheme, every one hastens through by-paths to private profit, no great change can suddenly be made; nor is superior knowledge of much effect, where every man resolves to use his own eyes and his own judgment, and every one applauds his own dexterity and diligence, in proportion as he becomes rich sooner than his neighbour.

Whosoever shall look heedfully upon those who are eminent for their riches will not think their condition such as that he should hazard his quiet, and much less his virtue, to obtain it, for all that great wealth generally gives above a moderate fortune is more room for the freaks of caprice, and more privilege for ignorance and vice, a quicker succession of flatteries, and a larger circle of voluptuousness.