Buffon said unreservedly, "Genius is simply patience carried to the extreme." To those who asked how he achieved fame he replied: "By spending forty years of my life bent over my writing desk."

Even granting that the genius subjected to the test of critical inspection emerges free from all error, we should consider that everything he has discovered in a given domain is almost nothing in comparison with what is left to be discovered.

In my own view, some advice about what should be known, about what technical education should be acquired, about the intense motivation needed to succeed, and about the carelessness and inclination toward bias that must be avoided is far more useful than all the rules and warnings of theoretical logic.

Buffon said unreservedly, "Genius is simply patience carried to the extreme." To those who asked how he achieved fame he replied: "By spending forty years of my life bent over my writing desk."

In summary, all great work is the fruit of patience and perseverance, combined with tenacious concentration on a subject over a period of months or years.

As long as our brain is a mystery, the universe, the reflection of the structure of the brain will also be a mystery.

The brain is a world consisting of a number of unexplored continents and great stretches of unknown territory.