The biggest challenge [making Pineapple Express] was that we had a comedy budget. We really got excited the more we got into the development of it about blowing stuff up and having shoot outs. That stuff costs money.

Every time I improvise I'm aware that I could be ruining what it is that we're doing and we'll just have to do it again.

When I was 13 and 14, there were a lot of jokes about my bar mitzvah and my grandparents, and then when I got older, it became more about touching boobs and trying to get liquor, you know? I kind of ran the gamut of infantile behavior... And I haven't moved one step forward since.

Every once in a while you definitely have to film someone for half an hour saying something that you do not think is funny because for the previous two hours they said a bunch of stuff that you think is really funny.

I remember thinking as I was doing the jokes for the first time, "If I can hear that very clearly, I'm not hearing laughter." It just became deafening, this buzzing noise. I mean, it was brutal. It was really terrible. Then I remember thinking, "At least nobody important, or anyone who I really respect, saw that." And then literally right when I went off the stage, Jerry Seinfeld got up and went on. So I was like, "Oh great. Seinfeld saw me bomb." On the other hand, I thought, "At least no one will be thinking of me anymore. They'll just be focusing on him."

If you take a tube TV to a donation center, they won't accept it.

We live in a world where in the movie you can disembowel someone in a youth hostel in Romania, but you can't show people having sex. I think it's weird.