We all have those dreams of going back in time and seeing what it was like when our parents were younger. Maybe we don't all have that dream. I don't know. Getting to role play or step back to a different moment in time and see things through a different lens is something that resonated with me, for sure. We don't get to do that, generally, but when the right neurological disorder lines up with the right unstable woman, that moment presents itself. Getting to know where we come from is a really profound way of getting to look at who we are.

I wanted to come to Chicago. I also wanted to do "Saturday Night Live." And then I got to a place where I didn't want to do those things anymore.For the sketch comedy thing, I got cast on "MADtv," and that will kill any man's desire to do comedy.

There's also these moments when you're like, oh, I really want to do different things. Not instead of this show [The Big Bang Theory]. It's just a hunger to do something else, too.

I had to learn all the pieces backward and forward [to play it in "Florence Foster Jenkins"]. We practiced on weekends. It was very much like being in school, except it was with Meryl Streep. Like, I would go to her apartment and we would practice Mozart's "Queen of the Night."

Meryl Streep is so brilliant is because she is so human, and aware as a performer.

To me the ambiguity is, maybe our perception of ourselves is always going to be different than somebody else's perception. There will always be that disparity.

I met a bunch of people and they said, "We're gonna do a show [Second City]." So we would buy the theater out and do a show, and we did that for five years and we ended up becoming popular. It was before sketch comedy was hipster-time - when you would hand out a flier, people would roll their eyes. Now it's kind of cool.