One can imagine that God created the universe at literally any time in the past. On the other hand, if the universe is expanding, there may be physical reasons why there had to be a beginning. One could imagine that God created the universe at the instant of the big bang, or even afterwards in just such a way as to make it look as though there had been a big bang, but it would be meaningless to suppose that it was created before the big bang. An expanding universe does not preclude a creator, but it does place limits on when he might have carried out his job!
Stephen HawkingThe increase of disorder or entropy with time is one example of what is called an arrow of time, something that distinguishes the past from the future, giving a direction to time.
Stephen HawkingThink of our DNA. In the last million years, our DNA hasn't changed at all. It's really much the same as it was in the jungle, a million, two millions years ago. But in the last 200 years, our destructive capacities have increased many, many millions of times over. Why don't we see intelligent signals from outer space? Because in all likelihood, once the civilization reaches the point our civilization has reached, it destroys itself.
Stephen Hawking