Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory.
There is no unique picture of reality.
Why does the universe go to all the bother of existing?
It matters that you don't just give up.
There is a real danger that computers will develop intelligence and take over.
Not only that God does play dice, but that He sometimes confuses us by throwing them where they can't be seen.