Let's take something like antidepressant medications. There's decent science saying it has an effect, but it's shockingly small after you control for penetration of the blind, people knowing that they're getting the active pills versus sugar pills, if you use an active control. It's probably only a few points. But it's a multi, multibillion-dollar industry. And by the way, has huge side effects. 40 percent of the people taking them have significant sexual side effects. And that's just one. A single antidepressant medication can be worth a billion dollars to a company.

Almost all people suffer some form of intense inner pain at some times in their lives. The suffering might be depression, anxiety, substance abuse, or suicidal thoughts and it results from the battles we wage against our thoughts as we futilely try to get rid of our historie.

The definition of happiness being very emotion-oriented - the problem is that there's too many quick and dirty ways to chase that in ways that end up being unhelpful to people. If you just have another martini or even more severe substances. But commercial culture and our media is constantly encouraging us to think that if we feel good we live well. We're only too happy to sell you goods and services from the dancing oivoids and the pill you can take, or the trips or the cars or the clothes or the women that you can get with - whatever that is that will give you the quick route to that.

There are times when you felt especially important to another person, or cared about or loved or accepted. Well, loving relationships aren't something you can have like a precious little jewel you put in a box and then put on your shelf. It's something you walk towards. And there's always difficulties; there's always pain in relationships. But you can keep walking towards that beacon in the distance. That process, that journey, is called life. And if you're moving towards the things that you value, life is more vital, flowing; it's more empowering.

One dangerous definition of happiness is to think of happiness as kind of a warm, joyful feeling in your heart that you have to pursue and grab and hold onto for fear that it'll go away. A better way to think about happiness that actually is something that I think you can reach towards is, it's living in accord with your values and in a way that is more open and accepting of your history as it echoes into the present, that's more self-affirming, self-validating and values-based. The Greeks had a word for it; they called it eudaimonia. And it is something that will empower human lives.

It's pretty clear in how things are moving in empirically supported treatments that we're going to be speaking to the culture in a different voice. It's going to have some echoes of some of the deeper clinical and spiritual and religious traditions that had wisdom in it. If we're not going to get there through religious means and things of that kind, we're going to have to find a way to put it in the culture in a different way, because we need something right now other than yet another cable shoutcast or yet another Internet Web page showing us the cellulite on the actress's rear end.

The changes that we can make in the culture can be there for people that we will never meet, that will never know us, and that's what keeps me up at night. It's what excites me about science, that we can learn ways of being with each other. And the behavioral sciences have not been enough of a part of cultural development. The physical sciences have; the behavioral sciences have not. And I would like to see if we can bring some things into human culture that would humanize and soften and empower people.