It's a long way from not having enough serotonin to thinking the world is "stale, flat and unprofitable"; even further to writing a play about a man driven by that thought.

I was trying to explain my situation to myself. My situation was that I was in pain and nobody knew it, even I had trouble knowing it. So I told myself, over and over, You are in pain. It was the only way I could get through to myself. I was demonstrating externally and irrefutably an inward condition.

Not everything has a happy ending, and not everything has an ending. Some things just kind of dribble away or cut off abruptly.

For nearly a century the psychoanalysts have been writing op-ed pieces about the workings of a country they've never traveled to, a place that, like China, has been off-limits. Suddenly, the country has opened its borders and is crawling with foreign correspondents, neurobiologists are filing ten stories a week, filled with new data. These two groups of writers, however, don't seem to read each other's work. That's because the analysts are writing about a country they call Mind and the neuroscientists are reporting from a country they call Brain.

Emptiness and boredom: what a complete understatement. What I felt was complete desolation. Desolation, despair and boredom.

Viscosity and velocity are opposites, yet they can look the same. Viscosity causes the stillness of disinclination, velocity causes the stillness of fascination. An observer can't tell if a person is silent and still because inner life has stalled or because inner life is transfixingly busy.

Which is worse, overload or underload? Luckily, I never had to choose. One or Pass on to where? Back into my cells to lurk like a virus waiting for the next opportunity? Out into the ether of the world to wait for the circumstances that would provoke its reappearance? Endogenous or exogenous, nature or nurture - it's the great mystery of mental illness.