...In the vast majority of drug experiments, it is not uncommon for none or one or two of hundreds of patients to benefit from the drug.

An attitudinal sea change. I think that's the hardest one to fix. Presidential directives, bills, provisions can all be rescinded, repealed, amended, but attitudes linger. The hardest thing is going to be to try to reverse an attitude, a bunker mentality that equates secrecy with either security or heightened efficiency and that regards transparency as an invitation to mischief and trespass. This default position of operating in the shadows is going to be somewhat appealing to whomever inherits office.

Every effort is made to control information. Secrecy is just one of the toggles on their control board. The mindset is in place, and they've done a lot of hiring over eight years, not just political appointees. And they've done a lot of firing or driving people out who might have countermanded or resisted. So, institutionally, it's not going to be simply a matter of flipping the switch to undo it. You're going have to bring in people dedicated to transparency, and you have to demonstrate that there are rewards for candor.

There are benefits in the sense that there's still a certain level of confidence. But there are liabilities because you can coordinate and manipulate better as the instruments of oversight are more under your control. You don't have so many rogue operations.

One of the principal factors fueling the proliferation of the abuse of secrecy and sensitive but unclassifieds is the administration's adherence to the unitary executive principal. This administration more than any of its predecessors believes that it is its responsibility to collect power onto itself in the executive office when it comes to the conduct of war, foreign policy, the management of agencies and departments, regulations, etc.

One of the things that will probably need to be addressed is in the treatment of history, i.e. the Presidential Papers Act. If they can act with impunity, if they know that what they're doing is not going to see the light of day anytime in their lifetime, if they have the right to withhold information from the public, then presidents are given a vastly freer hand.

The real secrets start leaking out when there are too many secrets because people can't remember what's a real secret. There's a very famous line by National Security Advisor McGeorge Bundy: "If you guard your toothbrushes and your diamonds with equal zeal, you'll lose fewer toothbrushes and more diamonds." And that's where we are right now.