The reason I am so passionately committed to the psychedelic thing is because I see it as radical, and if this is not the moment for radical solutions, what is?

The 'hard swallow' built into science is this business about the Big Bang. ... This is the notion that the universe, for no reason, sprang from nothing in a single instant. ... Notice that this is the limit test for credulity. . . . It's the limit case for likelihood.

We [psychonauts] are all going to go into the books as pioneers, because it's too early for us to be anything else. There's no map, no finished database, just anecdotes of the crazy, crazy stuff that goes on. That's why it's so important to try and share [our stories].

It's the impossible become possible and yet remaining impossible.

I would argue that it's almost better to do heroin than to watch TV. At least when you're doing heroin you're responsible for your own reveries and thought processes. When you're mainlining TV what is it but endless messages to fetishize products?

Although whenever you have intelligent life in the presence of large explosions, a safe bet is that the intelligent life is responsible for the large explosion.

I believe reality is a marvelous joke staged for my edification and amusement and everybody is working very hard to make me happy.