I have a disease, but I also have a lot of other things.

I refused David Letterman's proposal of marriage for obvious reasons, but thanks for asking.

Sandy: Boy, you must really think I'm stupid or something. Jeff: Ahh, no one would call you stupid, to your face.

You have to lift your head up out of the mud and just do it.

I take one of the interferon therapies, Rebif.

Any movie I've ever made, the minute you walk on the set they tell you who's the person to buy it from.

If there's ever a woman who's smart, funny, or witty, people are afraid of that, so they don't write that. They only write parts for women where they let everything be steamrolled over them, where they let people wipe their feet all over them.