I have always got medicine I want to give to people.

The English are such a frightened, nervous, insecure group of people - they no longer rule the world!

There was a perverse side of me, with things like Van Helsing coming out. I didn't want to go down that route.

I'm a cartoonist, it's what I am at heart, so cartoons take reality and deform it and make it grotesque, you make it funny, but you alter it. If it works, it's based on reality. That's what I try to do.

It's hard for me to worry about the studios losing money. I'm not very sympathetic to their money problems, because they certainly haven't been sympathetic to mine.

I never define depression, clinical or otherwise. It's the basis of most life, it seems to me, in the modern world. We're all depressed.

If you really want your films to say something that you hope is unique, then patience and stamina, thick skin and a kind of stupidity, a mule-like stupidity, is what you really need.