What can be accomplished by a few principles is not effected by many. But it seems that everything we see in the world can be accounted for by other principles, supposing God did not exist. For all natural things can be reduced to one principle, which is nature, and all voluntary things can be reduced to one principle, which is human reason, or will. Therefore there is no need to suppose God's existence.
Thomas AquinasMan can sin against nature in two ways. First, when he sins against his specific rational nature, acting contrary to reason. In this sense, we can say that every sin is a sin against man's nature, because it is against man's right reason.
Thomas Aquinas