The unavoidable price of reliability is simplicity.

Premature optimization is the root of all evil in programming.

Programmers are always surrounded by complexity; we cannot avoid it.... If our basic tool, the language in which we design and code our programs, is also complicated, the language itself becomes part of the problem rather than part of its solution.

An ultimate joint challenge for the biological and the computational sciences is the understanding of the mechanisms of the human brain, and its relationship with the human mind.

In the development of the understanding of complex phenomena, the most powerful tool available to the human intellect is abstraction. Abstraction arises from the recognition of similarities between certain objects, situations, or processes in the real world and the decision to concentrate on these similarities and to ignore, for the time being, their differences.

Inside every large program is a small program struggling to get out.

The price of reliability is the pursuit of the utmost simplicity. It is a price which the very rich may find hard to pay.