An ultimate joint challenge for the biological and the computational sciences is the understanding of the mechanisms of the human brain, and its relationship with the human mind.

You cannot teach beginners top-down programming, because they don't know which end is up.

Here is a language so far ahead of its time, that it was not only an improvement on its predecessors, but also on nearly all its successors.

I call it my billion-dollar mistake. It was the invention of the null reference in 1965.

Inside every large program is a small program struggling to get out.

The real value of tests is not that they detect bugs in the code but that they detect inadequacies in the methods, concentration, and skills of those who design and produce the code.

There are two ways of constructing a software design: One way is to make it so simple that there are obviously no deficiencies, and the other way is to make it so complicated that there are no obvious deficiencies. The first method is far more difficult.