Every big problem is a big opportunity.

Future is not extrapolation of past

It doesn't matter what your probability of failure is. If there's a 90% chance of failure, there's a 10% chance of changing the world.

Letting the perfect be the enemy of the good is one of the reasons we have a coal-dependent infrastructure, with the resulting environmental impact that all of us can see. I suspect environmentalists, through their opposition of nuclear power, have caused more coal plants to be built than anybody. And those coal plants have emitted more radioactive material from the coal than any nuclear accident would have.

The state of healthcare today is that we are busy in the practice of medicine vs. being in the science of medicine.

The world is hung up on food-based biofuels. Not only are they the wrong thing, they're the uneconomic thing.

Spreadsheets are fiction. Believing in what you're doing and what you're building is what's important.