Entrepreneurs have the flexibility and the ability to do things that large companies simply cannot. Could a large company pull off a trick like Amyris, going from anti-malaria medicine to next-generation fuel?

For electric power generation, we are very optimistic about solar-thermal technology, and we’re intrigued by the potential of enhanced geothermal energy to replace coal-based power generation. Traditional carbon capture and sequestration-based coal power generation is somewhat unlikely to be competitive.

It doesn't matter what your probability of failure is. If there's a 90% chance of failure, there's a 10% chance of changing the world.

Imagine the world of mobile based on Nokia and Motorola if Apple had not been restarted by a missionary entrepreneur named Steve Jobs who cared more for his vision than being tactical and financial.

I believe cellulosic fuels, biofuels made from nonfood crops are the only solution that will make a difference.

Seeking an acquisition from the start is more than just bad advice for an entrepreneur. For the entrepreneur it leads to short term tactical decisions rather than company-building decisions and in my view often reduces the probability of success.

Entrepreneurs have the flexibility and the ability to do things that large companies simply cannot. Could a large company pull off a trick like Amyris, going from anti-malaria medicine to next-generation fuel?