The first rule of venture capitalism is hands-on experience. You have to get your hands dirty.

It doesn't matter what your probability of failure is. If there's a 90% chance of failure, there's a 10% chance of changing the world.

Certain food-based biofuels like biodiesel have always been a bad idea. Others like corn ethanol have served a useful purpose and essentially are obsoleting themselves.

Big data will replace the need for 80% of all doctors

The only way you multiply resources is with technology. To really affect poverty, energy, health, education, or anything else - there is no other way.

I've probably failed more often than anybody else in Silicon Valley. Those don't matter. I don't remember the failures. You remember the big successes.

Imagine the world of mobile based on Nokia and Motorola if Apple had not been restarted by a missionary entrepreneur named Steve Jobs who cared more for his vision than being tactical and financial.