If you can socialize from the privacy of your desk at night in a dark room, you can be a smoother, cooler, funnier, sexy, more everything person than you actually are in real life.

Perhaps something like Facebook couldn't have been invented by somebody who goes out five nights a week and has a ton of friends and makes friends really easily.

Decisions are made by those who show up.

It was hard saying goodbye to the character and harder saying goodbye to the actor. When rumours started going around that Rob Lowe might be leaving I got an email from Josh Malina asking if I'd be interested in an actor who was cheaper and not as good looking. I wrote back, "Always", and that was that.

Government should be a place where people can come together, and no one gets left behind. No one…gets left behind. An instrument of good.

President Bartlet: There's a delegation of cardiologists having their pictures taken in the Blue Room. You wouldn't think you could find a group of people more arrogant than the fifteen of us, but there they are, right upstairs in the Blue Room.

When I feel that something I'm writing is going well, everything in my life is good and the things in my life that aren't good are completely manageable. If it's not going well, Miss America could be standing there in a swimsuit handing me a nobel price and I wouldn't be happy about it